GLIOBLASTOMA MULTIFORME
Client Case
We use Sakharoff Protocol
to change the cell environment and stop tumor growth
- Instead of only fighting the symptoms with targeted therapies
Stage 4 Glioblastoma Multiforme - A Story of Healing
This video shows a process of healing stage 4 glioblastoma multiforme brain tumor.
Diagnosis
Gert-Inge, 54 y.o, resident of Copenhagen, Denmark, started working with me right after the brain surgery on glioblastoma multiforme stage 4 brain tumor.
About Glioblastoma Multiforme
GBM (Glioblastoma Multiforme) is one of the most aggressive brain tumors that interferes with all bodily functions and leads to a very fast decline, slowly depriving a person of the ability to move, to communicate, and even to eat and drink.
GBM survival rates are one of the shortest of all brain tumors. Clinical trials of targeted therapies brought little survival benefits to GBM patients [1,37]. As you might already know, their median life prolonging effect is around 12 months in average, despite of lots of scientific trials [37,38].
GBM is considered incurable by conventional targeted approaches like chemotherapy, radiation and surgery because they don't change the environment in the brain in the long term - but only target the symptoms. It doesn't change the long-term prognosis for very agressive cancer cell populations with high grade of heterogeneity and diffusion among the normal cells.
Our non-invasive healing strategy
Targeting single genes will always remain the strategy of targeting single symptoms. Targeting single genes will never be able to address the real causes of a complex disease. This strategy has been shown to be a complete fallacy [1].
Many recent scientific studies show that metabolic approaches can stop and reverse terminal stages of cancer that are incurable by conventional medicine [2,3,4].
We worked together for 5 months. Our strategy was to use a Non-Pharmacological Metabolic Approach (NPMA) to address the metabolic causes of tumor - optimising brain cell environment. We used Sakharoff Protocol to change the body' cell environment and stop tumor growth - instead of only fighting the symptoms with targeted therapies as chemo and radiation.
We trained Buteyko method right from the start, first with small steps then with higher and higher intensity, slowly overcoming plateaus and moving further and further in the healing process.
We changed daily nutrition to make a slow transition to nutritional ketosis.
Clearly defined measurement targets
The whole idea with the intensive framework is targeted on several metabolic markers that are known to stop brain tumors (instead of traditional gene-specific tumor markers). All of the markers that we are using in Sakharoff Protocol are fully measurable. That shows the process of healing. We are waiting for the next scan in the middle of Oktober 2018 to confirm our presumption of Dr. Buteyko - tumours can not exist with MCP at a stable daily level ≥ 60 sec.
The splash you can see in the MCP and G/K lines show the phenomenon of "scanxiety" well known to all cancer survivors - nervousness before the scan that is influencing all the metabolic markers. Structured methods in our program are also addressing scanxiety through methods from the martial arts and samurai legacy - 1-pointed attention training with PAR (Progressive Active Relaxation).
Contact Information
Science & Practice - Misha Sakharoff: misha@sakharoff.com
Are You Diagnosed With Glioblastoma Multiforme?
The Sakharoff Protocol is a Non-Pharmacological Metabolic Approach (NPMA) that integrates the 5 main areas of human health into one structured program of training and assisted lifestyle change.
It targets cellular environment of the body as a whole - rather than the genetic expression of particular single genes involved in the tumor progression.
If you are interested to learn more please the click on the image below ⬇︎
References - Scientific Studies
- Altered energy metabolism in cancer – A unique opportunity for therapeutic intervention: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572003/
- T.N. Seyfried, Cancer as a metabolic disease: on the origin, management, and prevention of cancer, John Wiley & Sons, Inc, A. Hoboken, NJ, 2012. ISBN: 978-0470584927, ISBN:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102745/ - Metabolic alterations in cancer cells and therapeutic implications: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013402/
- Cancer as a metabolic disease: implications for novel therapeutics:
http://www.ncbi.nlm.nih.gov/pubmed/24343361
References - Scientific Studies
- DIPG Facts, Michael Mosier Foundation:
https://www.defeatdipg.org/dipg-facts/overview/what-is-the-treatment-for-dipg/ - Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637314/ - Ian F. Tannock, M.D., Ph.D., and John A. Hickman, D.Sc., Limits to Personalized Cancer Medicine:
https://www.nejm.org/doi/pdf/10.1056/NEJMsb1607705 - Altered energy metabolism in cancer – A unique opportunity for therapeutic intervention:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572003/ - Cancer as a metabolic disease: implications for novel therapeutics:
http://www.ncbi.nlm.nih.gov/pubmed/24343361 - T.N. Seyfried, Cancer as a metabolic disease: on the origin, management, and prevention of cancer, John Wiley & Sons, Inc, A. Hoboken, NJ, 2012. ISBN: 978-0470584927, ISBN:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102745/ - Metabolic alterations in cancer cells and therapeutic implications: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013402/
- T. Ferriss, Tools of Titans, Boston, Houghton Mifflin Harcourt Publishing Company, 2016. Interview with Dominic D'Agostino.
- Z. Clemens, C. Toth, TREATMENT OF HIGH-GRADE BRAIN TUMOR USING THE PALEOLITHIC KETOGENIC DIET (PKD): THREE CASES:
https://www.researchgate.net/publication/322570681_TREATMENT_OF_HIGH-GRADE_BRAIN_TUMOR_USING_THE_PALEOLITHIC_KETOGENIC_DIET_PKD_THREE_CASES - M.J. Bissell, H.G. Hall, G. Parry, Dynamic reciproity: How does the extracellular matrix direct gene expression?, J Theor Biol 99 (1982) 31–68:
https://www.sciencedirect.com/science/article/pii/0022519382903885?via%3Dihub - Normalbreathing.com. All clinical trials of the Buteyko method: http://www.normalbreathing.com/practice-trials.php
- M. Sakharoff, The Taste of Victory – Beating Cancer Natural Way:
https://sakharoff.com/the-taste-of-victory-beating-cancer-natural/ - M. Sakharoff, Learning points from the remission of Glioblastoma Multiforme brain tumor:
https://sakharoff.com/learning-points-remission-brain-cancer/ - State of affairs in use of steroids in DIPG: an international survey and a review of the literature:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901114/ - Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312317/ - Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525007/ - Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma:
https://www.researchgate.net/publication/320724464_Combination_of_EZH2_inhibitor_and_BET_inhibitor_for_treatment_of_diffuse_intrinsic_pontine_glioma - Gang Wu et al, Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas:
https://go.nature.com/2Nxcm0b - C.A. Godman, et al., Hyperbaric oxygen treatment induces antioxidant gene expression, Ann N Y Acad Sci 1197 (2010) 178–183:
https://doi.org/10.1111/j.1749-6632.2009.05393.x - T. Shimazu et al, Suppression of Oxidative Stress by Beta-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor:
http://www.insanemedicine.com/wp-content/uploads/2016/05/Suppression-of-oxidative-stress-by-%CE%B2-hydroxybutyrate-an-endogenous-histone-deacetylase-inhibitor..pdf - Mithu Storoni and Gordon T. Plant, The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis:
https://www.hindawi.com/journals/msi/2015/681289/#B66 - F. Karami, P. Mehdipour, Cancer Genetics and Psychotherapy:
https://bit.ly/2wpuUZU - M.A. Makary, M. Daniel, Medical error—the third leading cause of death in the US, BMJ 353 (2016) i2139:
https://doi.org/10.1136/bmj.i2139 - B.T. Seyfried, M. Kiebish, J. Marsh, P. Mukherjee, Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet, J Cancer Res Ther 5 (Suppl 1) (2009) S7–S15:
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=9;spage=7;epage=15;aulast=Seyfried - A. Poff et al, Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma:
https://www.ncbi.nlm.nih.gov/pubmed/29294371 - D.E. Bredesen, Reversal of cognitive decline: a novel therapeutic program, Aging (Albany, NY) 6 (2014) 707–717:
https://doi.org/10.18632/aging.100690 - Bissell, M.J. and Radisky, D. (2001) Putting Tumours in Context. Nature Review Cancer, 1, 46-54.
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- Fasting – Molecular Mechanisms and Clinical Applications:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/
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https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0009-2 - S.N. Paschenko, Study of application of the reduced breathing method in a combined treatment of breast cancer, Oncology (Kiev, Ukraine) 3 (1:) (2001) 77–78.
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Jersey, 2013244–245. - B.S. Oken, I. Chamine, W. Wakeland, A systems approach to stress, stressors and resilience in humans, Behav Brain Res 282 (2015) 144–154
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and health, John Wiley & Sons, Chichester, UK, 1988, pp. 629–649, 1988. - M. Abedin, N. King, Diverse evolutionary paths to cell adhesion, Trends Cell Biol 20 (12) (2010) 734–742. https://doi.org/10.1016/j.tcb.2010.08.002
- J. Backer, J. Dice, Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced by serum withdrawal, Proc Nat Acad Sci USA 83 (1986) 5830–5834.
- M.H.A. Jansen et al, Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology:
http://www.stichtingsemmy.nl/wp-content/uploads/Jansen-Cancer-Treatment-Rev-20121.pdf - B. Benitez, Brainstem Tumours in Children:
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About Sakharoff Integrative Health
OUR VISION
- To empower people through integrative approach to rediscover the natural healing powers of their body, so they can take back responsibility for their health.
- To move from sick-care to health-care and towards non-invasive metabolic therapies – instead of constantly finding new genetic pathways to promote the current business model based on creation of new highly invasive chemical drugs.
- To bring forth a paradigm shift towards education instead of medication.
- To move back to the old model of medicine. Here, doctors were rewarded for their success in keeping their patients healthy - instead of being paid for trying to heal them when they got sick.
OUR STRATEGY
- Sakharoff Integrative Health protocol is a NPMA - Non-Pharmacological Metabolic Approach. As such it does no harm in the medical sense, it does not use any medical substances and basically doesn’t require any special equipment. We don’t sell neither the substances or the equipment. We only provide education and training to optimize the body functions essential for health and resilience. We also provide daily assistance to our clients to ensure 100% compliance regarding their activity and measurement regimens.
- Sakharoff Protocol promotes not either-or, but both-and. It means that the idea of integrative health has to be promoted. We connect the dots - not only nutrition, not only breathing, not only movement but all of that combined in one process.
- Sakharoff Protocol is in many ways complementary to the work of doctors that are openminded. Our common understanding is that the source of chronic diseases is metabolic dysfunction triggered by wrong lifestyle, through expression of a person's unique DNA.
- Sakharoff Protocol uses scientific research studies as the foundation for its core teachings and exercises.
- Sakharoff Protocol looks at triggers and causes of the disease - not only the symptoms. The protocol promotes understanding of lifestyle disease as syndrome with metabolic disfunction - multi-factorial condition with a bouquet of symptoms. Eg. people with Alzheimer’s most often than not get both diabetes and cardiovascular disease and other symptoms of metabolic dysfunction.
- Sakharoff Integrative Health work on two levels of interest. Firstly, helping individual person taking responsibility for his/her own health. Secondly, with the whole society, facilitating the paradigm shift from the practice of conventional allotropic medicine towards the idea of integrative metabolic health.
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