BEAT GBM
Intensive Bootcamp
We use Sakharoff Protocol
to change the brain cell environment and stop tumor growth
- Instead of only fighting the symptoms with targeted therapies
Diagnosed with GBM?
You are diagnosed with GBM (Glioblastoma Multiforme), one of the most aggressive brain tumors that interferes with all bodily functions and leads to a very fast decline, slowly depriving a person of the ability to move, to communicate, and even to eat and drink.
It's a terrible situation that pushes you up a blind alley. It's even harder in a situation where the conventional medicine apparently does not offer options.
But there is an option. Please read on carefully.
Is BEAT GBM Bootcamp
for you?
BEAT GBM Intensive Bootcamp is for you if you are newly diagnosed with a high-grade brain tumor as GBM and can say YES to one or more of the following criteria:
Katrine Flindt MD
Medical Director of IOM Clinic, a functional medical clinic in Denmark
The aggressive brain tumors are considered almost impossible to cure. Very few patients survive. Even the best neurosurgeons and oncological teams have low survival rates. The Sakharoff Protocol is an attempt to change the paradigm. Misha Sakharoff and his team introduce a whole new range of interventions, that have never been used in such a comprehensive setting - and which are simultaneously totally non-toxic.
I see Sakharoff Protocol as the first attempt to integrate interdependencies of cellular and mitochondrial metabolism with lifestyle, behaviour and training routines. The fact that this bootcamp provides its participants with daily practical assistance through 26 weeks gives hope that it will be possible to actually stop and reverse proliferation of the agressive high-grade tumors like GBM and DIPG. I will follow this bootcamp closely.
BEAT GBM! Intensive Bootcamp is open for enrolment
All applicants have to pass through a 30-min personal interview session with me on Skype. This interview is free of charge - If you are admitted the monthly cost will be 770$.
Time for Paradigm Shift
Scientific research on stopping GBM started in the seventies. Since then the medical profession has tried to apply chemotherapy, surgery, radiation and proton therapy to fight this terrible condition.
Conventional therapies like surgery, chemo and radiation have a positive result - adding average extra 12 months to the average GBM life expectancy [1,2].
Despite these scant results the medical profession is still putting all their eggs in the same basket as before - trying to discover genetic expression pathways to use with the new targeted approaches[3]. The recent decades of genetic research for reversal of lifestyle diseases have resulted in a myriad of drug types that have proven to be useless and, at worst, life-shortening. The expenditure in the field of neurodegenerative diseases is called by some scientists "The Game of Throwns", relating to the immense amount of money spent on research and development of targeted approach medicines - with no result whatsoever.
These scientists start realizing that GBM (Glioblastoma Multiforme), DIPG (Diffuse Intrinsic Pontine glioma) and other high-grade brain tumors are, in fact, multifactorial syndromes [4] - and not single factor diseases as they are being treated by the mainstream science, still trying to find one "magic pill".
The single-factor approaches targeted at particular genetic expression pathways can not be expected to show results with multi-factorial syndromes. There are hundreds of genes involved in the complex multifactorial syndromes as GBM and DIPG - just as in the cases of other types of cancer.
Targeting single genes will always remain the strategy of targeting single symptoms. Targeting single genes will never be able to address the real causes of a complex disease. This strategy has been shown to be a complete fallacy [4].
GBM and DIPG are still deadly - just as 40 years ago. With 5 year survival rates of 5% for GBM and 1% for DIPG. Conventional approaches failed finding the cure for GBM and DIPG.
I think it's high time to use a different approach - a paradigm shift:
Is There Any Hope?
Many recent scientific studies show that metabolic approaches can stop and reverse terminal stages of brain tumors as GBM that are incurable by conventional medicine.
Experimental metabolic approaches by Prof. Thomas Seyfried from Boston College Biology Department [5,6], Dr. Dominic D'Agostino from University of South Florida College Of Medicine [7,8] and Dr. Scaba Toth from Paleomedicina Hungary [9] prove this, as well as the experimental work of Mina Bisell [10] with the normalization of cancer cell environment called extracellular-matrix (ECM).
I used the inspiration from these doctors' novel metabolic approaches and combined it with something they all are lacking. I'm talking about optimization of oxygenation on the cellular level that are powerful features of Buteyko [11] breathing therapy - as well as a whole array of other novel techniques. The resulting Sakharoff Protocol is engineered to combine optimization of the 5 main areas of human health to achieve dramatic synergetic effect on the brain cell environment.
I formulated this protocol during the last 8 years work as a therapist with my 1-on-1 clients. In the process I combined my experience as engineer, project manager, mental trainer, bodywork instructor and breathing therapist.
The healing effect of Sakharoff Protocol is fully trackable through daily measurements of blood, breathing, sleep quality and other parameters.
The Sakharoff Protocol has helped a number of clients with Glioblastoma brain tumors and other forms of cancer.
That's exactly why I decided to make this BEAT GBM Intensive Bootcamp. I want to use all my experience to build an intensive framework for a structured daily attempt to stop GBM.
BEAT GBM Intensive Bootcamp uses Sakharoff Protocol as a metabolic approach optimizing the brain cell environment to stop tumor growth - instead of only fighting the symptoms with invasive targeted therapies.
The Sakharoff Protocol can be used both in parallel with the course of radiation as prescribed by your doctor - as well as a stand-alone therapy, if you might decide to opt-out of radiation. Both ways could work and have their own pros and cons.
BEAT GBM Intensive Bootcamp will provide you with the knowledge, the training routines and the 7-days a week support for an assisted lifestyle change and structured exercise needed to transform the brain environment to an uninhabitable place for cancer cells.
The image below pictures a hope - and a victory. “I don’t really understand how to explain this with my knowledge of physiology”, one of the most experienced neurosurgeons in Denmark said looking at the latest brain scan of my client with Glioblastoma Multiforme IV – the most aggressive malignant brain tumor. “It looks like the tumor is gone – the only thing left is scar tissue…” [12,13]
The Sakharoff Protocol
-Non-Pharmacological Metabolic Approach
The Sakharoff Protocol is a Non-Pharmacological Metabolic Approach (NPMA) that integrates the 5 main areas of human health into one structured program of training and assisted lifestyle change. It targets cellular environment of the brain as a whole - rather than the genetic expression of single genes involved in the brain tumor progression.
A Non-Pharmacological Metabolic Approach has a few prerequisites in order to succeed:
How Can we Stop Growth of a High-Grade Brain Tumor Without Drugs?
PUSH HERE --> TO READ A FULL TRANSCRIPT OF MISHA SAKHAROFF'S PERSONAL MESSAGE
BEAT GBM! Intensive Bootcamp is open for enrolment
All applicants have to pass through a 30-min personal interview session with me on Skype. This interview is free of charge - If you are admitted the monthly cost will be 770$.
Inclusion Criteria
Unfortunately we need to have inclusion criteria because the only chance to help you or your children recover with our program is through intensive daily exercise and nutritional change. Those are absolute prerequisites to succeed.
These regimens require the ability to stand and move, as well as ingest/digest strictly animal sourced fats and protein. That’s why admission to our program requires the following:
If you are unsure whether or not your situation complies with the inclusion criteria,
please contact me directly:
Book a free 15-min call with Misha Sakharoff
Why You Need to Act Now
It is crucial to understand that there are only two short periods of time that open up for the opportunity to stop proliferation of the tumorous cells:
1. Shortly after the diagnosis and before the course of radiation
2. Shortly after the completion of the initial course of radiation
Why? Because these two short periods give the diagnosed person the best chance to endure the course of intensive structured training and lifestyle change. Both situations represent a window of opportunity.
I call it the window of opportunity because I know that when we cross the line of the later stages of tumour proliferation it will be too late. At this stage the severe side effects of anti-inflammatory steroid and other medications prescribed as supportive or palliative treatment will reduce the quality of life in such extent that - it will rule out the ability to endure intensive structured training [14].
Crossing the line of the later stages of tumour proliferation is called point of no return because the quickly degrading physical ability (musculoskeletal, organ function) as well as attention, awareness will eliminate all chances of active daily effort. I'm talking about 3 prerequisites of success related to the window of opportunity and ability to endure a structured daily effort:
Sakharoff Protocol is engineered to utilize this window of opportunity with maximum efficacy.
We strongly prioritize starting with the changes that are most crucial and promote maximum effectiveness already during week 1 of our BEAT GBM Intensive Bootcamp.
In this way we can help you to start establishing a strong and lasting process of healing - right away. This can be done through prioritizing enhancement of the body's energy supply and utilization - through coordinated effort on the fields of: optimization of breathing, nutrition, physical training, and lifestyle intervention.
BEAT GBM! Intensive Bootcamp is open for enrolment
How Can the Non-Pharmacological Metabolic Approach Save GBM Lives
- Where the Conventional Medicine Can Not?
This question doesn't have only one answer. In fact, there are several factors that explain why NPMA healing strategy should be the choice for you to battle a high-grade brain tumor:
Heterogeneity
The most aggressive brain tumors like DIPG (Diffuse Intrinsic Pontine Glioma) or GBM (Glioblastoma Multiforme) require intensive therapy, because of their highly mutated DNA with a great degree of heterogeneity.
Heterogeneity means that the population of cancer cells is derived from many different DNA mutations. The higher the heterogeneity, the harder it is to target tumors with the conventional therapies. That is why Glioblastoma is called “The Terminator” and it is said that once we can defeat DIPG we can defeat all the cancers.
The terms 'Multiforme' in GBM and 'Diffuse Intrinsic' in DIPG are all closely related/ synonymous and describe the tumor cells' ability to spread diffusely throughout the normal structures of the brain.
Multifactorial conditions
As I already said, I don’t believe that it will be possible to find a single-factor treatment or a 'magic pill' for this type of tumors, because just as other types of cancers - they are multi-factorial conditions. Targeted approaches are not efficient against multi-factorial conditions - and they will never be. The magic pill is a beautiful picture - but also an absolute illusion.
But We Don't Know
The Causes of GBM - Do We?
Many scientific studies on metabolic approaches show that changing the cell environment can inhibit tumor cell growth and disrupt the tumor metabolism, reversing the disease by eliminating its causes [5,6,7,8,9,10,11].
But you might say - We don't know the causes of GBM, right?
GBM as all other brain tumors is caused by genetic mutations in the brain cells. Cell mutations occur mostly because of the abnormal cell environment. They are called epi-genetic mutations.
Scientific research on GBM
There are several studies that show that epi-genetic mutations and modulators are involved in the genetic pathways as EZH2, BET, HDAC, Histone H3 that are connected specifically to development of DIPG and GBM tumors [15,16,17,18]. This profound scientific research is targeted on better understanding of epi-genetic pathways which inhibit genetic expression and which lead to cancer proliferation - gene inhibition and transcription disruption.
The strategy of targeting single genetic pathways is a fallacy. Cells within a single tumor can acquire different mutations, such that “even if there is an effective agent, it is likely to have limited benefit because molecular pathways that are active in other parts of the tumor will lead to tumor growth from different clones of tumor cells".
Unfortunately this research is focused on development of drugs targeting these particular genetic pathways - and not on metabolic approaches. Despite the fact that these approaches target the same biochemical and epigenetic pathways - but non-invasively, through exercise and nutritional lifestyle change. There are many examples to this:
- Breathing - optimization of cell oxygenation
Using hyperbaric oxygen therapy HBOT though there is evidence showing that it can have deleterious effect on oxygen saturation in the tissue and increase the production of reactive oxygen species (ROS) causing oxidative stress in body tissues [19]. At the same time an NPMA as Buteyko therapy would exert a more perfectly graded hormetic effect here being potentiated by the increased sensitivity of the sick person during training.
- Nutrition - optimization of lipid breakdown by the cells
There are studies showed that BHOB (Beta-hydroxy-butyrate) one of products of fat breakdown in the liver is inhibiting the genes causing oxidative stress in the tissue - that promotes tumor growth [20]. BHOB is naturally abundant in the body in the later stages of ketogenic adaptation, which can be achieved by assisted lifestyle change and strict compliance to the nutritional regimen [21].
- Mental resilience
There are also studies showing that psychological factors increase gene expression which might trigger genetic GBM pathways[22].
Tumor reversal is possible only through change in the cell environment
I believe that the most aggressive cancers and brain tumors can be reversed through multifactorial NPMA. It means that we can reverse the complex disease by induce the change in the dysfunctional cells - through changing their environment.
In order to reach strong synergetic effect of multifunctional therapy we need to combine several strong therapeutical approaches in one highly structured and supervised process of self-healing. If we make the process of change highly structured we can beat cancer - against the heavy odds. Especially when it is newly diagnosed.
But...
You Need To Break the Taboo and
Change the Rules of the Game
When a doctor has told you that you are about to lose your own life or your child's life to this dreadful tumor, you go into a phase of shock and disbelief. The first thoughts are:
We are used to perceiving doctors as the helpers who can always make a difference. But the habitual view is deceiving. Unfortunately, it is correct when the doctor points out that using conventional medicine, the best forecast for GBM is an extra few months' survival.
It is important to understand that the battle for survival is not yet lost. You must keep your head cold and make responsible decisions for yourself or/and your child. You must be able to talk about what is probably the biggest challenge you have ever faced.
In this situation, we often end up being uncertain and undecided. This situation triggers emotions so strong that we can hardly speak about it - and even less relate analytically to it. The dreadful truth might turn into a closed taboo subject. And it often does.
More often than not the newly diagnosed choose to follow the recommendations of the hospital and the doctor - forced by the following questions that remain unanswered:
You need to take personal responsibility for breaking the taboo and answering the questions above.
The doctors can simply not be your only advisers here. You also need to have your voice heard here - and be able to change the rules of the game.
Why Can Doctors Not Advise on Metabolic Approaches?
Doctor's specialization
Truth is that most doctors are strictly specialized in their own field and know nothing or close to nothing about Non-Pharmacological Metabolic Approaches (NPMA). They are professional in analyzing the symptoms to make a diagnose and prescribe a combination of medicines that fits your condition - and can eliminate the symptoms.
Most doctors are simply not educated in approaches addressing the metabolic triggers - the causes of the disease.
Doctor's field of experience
They are simply not aware of the strength of metabolic therapies, because they have never used them. They never had a close personal experience with the healing cases based on metabolic approaches. Most of the doctors never had any education targeted on understanding of metabolic causes of cancer.
Doctor's belief system
Most of the doctors - just as most of the patients - are induced to believe by the pharmaceutical industry to think that cancer is a strictly genetic disease. The fact is - it is NOT, because the genes are triggered towards expression by our degenerative lifestyle. So the genetic link is a secondary downstream phenomenon - not the primary one. Hence we can not simply count on our genes - without taking care of their environment.
Doctor's time and the guidelines
Most of the doctors don't have time to follow the latest developments in the fields neighboring to their own. Furthermore they need to follow their guidelines assigned by their medical authorities. Those guidelines contain protocols as chemo, radiation and surgery - invasive protocols that influence the survival rates of GBM so negligibly little.
Why Is It So Hard Both For Us and The Doctors To Break the Taboo?
Fear and ignorance
Truth is that most of us are ignorant when we are in the pressed situation. To break a taboo and think independently of the official conventional advice requires education from one side - and openness and readiness from the other. Which is virtually impossible because fear drives people from the moment they get a cancer diagnosis.
Only a few have intelligence and the guts to go against the strong current of conventional thinking and the one-sided industry propaganda promoting pills and other products. It makes chemo, radiation and surgery the only viable option for the most of us [23].
Education model
The existing education model is not integrative enough to cover all the aspects of our physiology. The basis of the current model is professionals telling the population that their area is the strongest one. This model is not viable enough to be able to establish and support a really strong healing process. For that, we need the synergetic effect of multifunctional training in different fields of health - in parallel.
The integrative education, based on long-term intensive bootcamps with both teaching, assisted training, daily nudging and thorough process building did not exist in the field of cancer treatment. Until now.
Broad definition of alternative
Education is very limited and of very differing quality. Alternative medicine is often defined by the broad spectrum of techniques ranging from the use of healing stones and reading the aura to herbs and acupuncture. Some of the methods are more scientifically proven than others.
Ingrained patient role
The basis of many therapies are interventions made by another person - hence the word patient. Why? Because it is about patiently waiting while the doctor or another medical professional fixes your condition.
In contrary, all the strongest metabolic therapies are based on the ill-health individual him-/herself working on a daily basis on reversing his/her condition. There is not necessarily a healer on the other side. But hopefully, an educator, coach and philosopher - for teaching, daily support and inspiration.
Role of cancer organizations
All the cancer foundations refuse to work with unconventional metabolic therapies, simply because they will lose their support from the medical companies and the government. They also lack the knowledge to be able to explain and promote the unconventional non-invasive metabolic therapies to their members.
What is the taboo anyway?
All of these aspects altogether make It very Hard Both For The Doctors from one side and us as their patients To Break the Taboo. This taboo is about an individual him-/herself taking responsibility for own health.
Taking Personal Responsibility
- Our Only Chance
If you wait and see what the hospital and doctors can set up, the time will go by. The hours will be days and days will be weeks. Your window of opportunity to apply NPMA approach and have a chance to let it work will shrink all too fast.
When we are talking about the treatments for GBM, we have to be aware of the fact that all the conventional medical recommendations given by the hospital and the doctor have until now showed to be blind alleys.
This fact applies to all GBM-diagnosed persons.
This is about your or your child's life - this is now that you have to take responsibility in your own hands.
You have to be aware that the doctor's conventional medical advice - and this BEAT GBM Intensive Bootcamp have two very different horizons:
We have a plan!
There is an alternative to the conventional approach to GBM that can be both real and workable.
We view tumors as systemic syndromes
Brain tumours as GBM are multifactorial syndromes - and not single factor diseases as they are still treated by the mainstream medicine.
There are hundreds of genes involved in the complex multifactorial syndromes that feed tumors via a myriad of pathways. Tumors consist of abnormal cells. Cell abnormality is a symptom of a biochemical imbalance in the body that is constantly maintained by a myriad of pathways. That biochemical imbalance can be corrected with a well-designed, metabolic program which can stop tumorous growth.
We help you build a non-toxic tumor reversal program
Building up a non-toxic, biologically sound program, focusing on the whole body and not just the tumour, we can provide all the biochemical building blocks and cell environment conditions necessary to stop and reverse the tumor, restoring normal health.
It’s a different concept of cancer and chronic degenerative conditions than the one promoted by conventional medicine. There is no magic bullet, no miracle drug or botanical ingredient that can heal cancer.
We help you to take responsibility
You have to take responsibility for your healing process, and the BEAT GBM Intensive Bootcamp program will support you by giving you tools and training.
You will learn how to make your body’s immunity as strong and inhospitable to cancer cells as possible. Our plan is to help you reach a strong synergetic healing effect.
We help you to make a transition
During the course of 6 months we will help you make a transition to a health regimen that includes breathing optimization, therapeutic nutrition, structured movement, stress management and immunity work.
BEAT GBM Bootcamp Content
The healing doesn't happen overnight. We engineered this BOOTCAMP to help you take active steps every single day during a period of 6 months. And we have a plan that have already succeeded reversing illnesses inclusive brain tumors as Glioblastoma Multiforme and other cancers, as CLL and AML leukemias, breast and ovarian cancers among others.
Week by week during 6 months you will learn the theory and practice of Non-Pharmacological Therapeutic Approach and apply it in your own daily practice - in the environment of your home. Our plan includes the following areas of active daily effort:
What Happens After You join
BEAT GBM is an online bootcamp. That means you will receive all the learning materials in the safe environment of your home 7 days a week. So it's not just another online bootcamp. It's a very intensive bootcamp tailored specially for people diagnosed with acute high-grade brain tumor as DIPG or GBM. The structure of BEAT GBM Intensive Bootcamp reflects this.
You will have a possibility to join the 1 hour LIVE Q&A sessions to answer your questions 5 days a week - from Monday to Friday. You will also be a member of a closed Facebook group. This means that you get an indispensable community with the other participants of the BEAT GBM Intensive Bootcamp and direct access to being guided personally by me.
The BEAT GBM Intensive Bootcamp will last for 6 months - with a possibility for extension. This means that you will get the material in manageable portions, and you will have plenty of time for implementation - diminishing the risks for overwhelm.
If you meet the inclusion criteria and decide to join the bootcamp after the personal interview, you will start on Monday 1st of October.
The weekly program for The BEAT GBM Intensive Bootcamp is as follows - all the times beneath are in your own time zone (except the daily Q&A time):
Monday
- Every Monday at 5am you will receive the introduction video of the week, which introduces the week's physiology topic in relation to healing of cancer and what you should pay particular attention to.
- Every Monday at 6am you receive the week's first video package with 3 videos: Video-1 is a general introduction to the week's topic. Video-2 talks about the week's topic in relation to basic physiology and recent research. Video-3 introduces the practical training of the week.
It is important that you always watch these videos in the order you receive them.
- Every Monday you can join our 60-min Online Q&A. To be sure to have your questions answered you will have to submit your questions to our closed Facebook group at least 2 hours before the session begins.
Tuesday
- On Tuesdays, you get extra material (audio file or PDF) to assist and nudge you in your own training process.
- Every Tuesday you can join our 60-min Online Q&A. To be sure to have your questions answered you will have to submit your questions to our closed Facebook group at least 2 hours before the session begins.
Wednesday
- On Wednesdays, you receive the second video package of the week, which has the same structure as Monday: Video-1 - General Introduction. Video-2 - on the subject in relation to basic physiology and recent research. Video-3 - Practical training of the week. It is important that you always watch these videos in the order you receive them.
- Every Wednesday you can join our 60-min Online Q&A. To be sure to have your questions answered you will have to submit your questions to our closed Facebook group at least 2 hours before the session begins.
Thursday
- On Thursdays, you get extra material (audio file or PDF) to assist and nudge you in your own training process.
- Every Thursday you can join our 60-min Online Q&A. To be sure to have your questions answered you will have to submit your questions to our closed Facebook group at least 2 hours before the session begins.
Friday
- Friday is the day of research on cancer, where we present some of the researchers behind the studies we refer to as well as practitioners who are leaders in their field.
- Every Friday you can join our 60-min Online Q&A. To be sure to have your questions answered you will have to submit your questions to our closed Facebook group at least 2 hours before the session begins.
Saturday
On Saturday you receive a nudging audio-file with inspiration from the nature, made specially to encourage you to get out into the nature and be energized.
Sunday
Sunday you receive an audio file that recaps all the main learnings of the week.
Your daily Q&A time Monday-Friday - in different time zones:
What to Expect - Stages of Healing
1st stage target
Our first target in the process of healing brain tumor is to stop intracranial pressure from building up. The build-up of intracranial pressure is the main issue of brain tumors because it directly causes the disabilities that can prevent and in the end disallow the active daily effort towards healing.
Less intracranial pressure will expand our window of opportunity with possibility for active daily effort and give us extra time to heal. We can prevent intracranial pressure build-up by a combination of intensive breathing exercise, stage-wise shift to nutritional ketosis and daily structured movement. All these regimens are taught during the first month of our BOOTCAMP.
The effect of our program is measurable. The most important measurement here is the amount of pain experienced. We expect the pain to stagnate and slowly reduce during the first month of intensive - and full compliant training.
It's very important that we start reducing the daily doses of steroid medication right away. Steroids are known to cause severe side effects and have a potential to slowly reduce quality of life in such extent that it will rule out the ability to endure intensive structured training. We need to avoid [14] that!
2nd stage target
When the pain is slowly reducing we will experience stagnation and slow reduction of other symptoms and disabilities. The signs of bettering could be seen in the improved ability to move, to do physical exercise, better digestion and better mood.
3rd stage target
To make the tumor shrink is our absolute and most crucial goal. It happens as a result of strong synergetic effect derived from all of the practiced regimens combined.
BEAT GBM! Intensive Bootcamp is open for enrolment
Sakharoff Protocol - Why It Works
There’s a lot of serious research going on in the field of non-invasive metabolic therapies. Several university hospitals in US and Europe are running metabolic studies about normalizing the gut flora, optimizing breathing, stopping systemic inflammation, activating lymphatic/ glymphatic flow, optimizing sleep, going through structured movement training programs - making a strong and lasting lifestyle change. Some of them are using supplementation and sometimes some additional targeted drugs.
Examples are Dr. Thomas Seyfried’s [5,6,24] and Dr. Dominic D’Agostino’s [7,8,25] successful work with cancers/ brain tumors and Dale Bredesen’s work with reversing Alzheimer's without medicine - with success in 9 out of 10 cases [26].
Our anti-tumor solution is based on Sakharoff Protocol, that integrates several main areas of human health into one structured process of training and lifestyle change. This protocol is inspired by the work of the beforementioned scientists and other researchers in the field of metabolic approaches. The idea behind Sakharoff Protocol is to visualize and map the connection between the cellular and the human environment in order to open up for measurable effects on health and resilience through training and lifestyle change.
As engineer I'm inspired by the theory of “dynamic reciprocity” [10] proposing that the cellular microenvironment in form of the extracellular matrix (ECM) exerts physical and biochemical influences on a cell, which ultimately affect changes in gene expression in the nucleus. Latest research on metabolic origins of lifestyle diseases, including the experimental work of Mina Bisell with the normalization of cancer cell environment called extracellular-matrix (ECM), further confirms the critical role of the microenvironment in regulation of genetic expression and cellular health [27].
Sakharoff Protocol - Main Strategy
My idea with the Sakharoff Protocol is that the main areas of cellular microenvironment can be optimized through structured training and lifestyle change. Hereby the 5 main areas of practical training (human macro-environment) are structured to fit 5 main areas of cellular health (cellular micro-environment, ECM).
The strategy is to integrate all the 5 main areas of practical training and lifestyle change, so they can be exercised interdependently through 1-pointed focus with Progressive Active Relaxation (PAR). This contributes to optimized energy utilization and performance coefficient minimizing energy loss. Kaizen process philosophy is used to establish strong practical approach to process implementation into small daily routines [28].
The figure below presents a mapping of dependencies in the connection between the main 5 areas of the human and the cellular environment.
Sakharoff Protocol - How It Works
These 5 main areas of practical training create a strong synergetic effect when combined together into one structured process and can be divided into two groups, as follows:
GROUP 1 - Optimization of Energy Intake
Energy acquisition from the environment can be optimized through fields of breathing and nutrition. Energy intake can be subdivided into two main areas of practical training and lifestyle change as follows:
- Nutrition
Effective transition to therapeutic nutrition through cancer-fighting and immune-boosting nutritional regimen. This dietary regimen will shift brain cells to full range fat burning and independency from glucose. That will drastically lower body glucose under the levels that stop chronic inflammation - which correlates with cancer proliferation and metastatic activity.
At the same time this regimen will ensure full elimination of all possible foods that can trigger autoimmunity and inflammation.
Optimization of nutrition has a direct effect on digestion of nutrients through the digestive system and absorption by the cell. Tools used in Sakharoff Protocol combine restricted ketogenic diet (CRKD) with a strict elimination protocol to avoid the main dietary triggers of autoinflammation. It also involves fasting regimens - both intermittent fasting (IF) and extended water fasts (2–5 days) [29].
The whole BEAT GBM Intensive Bootcamp framework is targeted on the novel metabolic markers that are known to stop brain tumors - instead of traditional gene-specific tumor markers.
The progress is measured through clearly defined measurement targets metabolic markers. G/K ratio is one of the novel metabolic markers, which is a ratio of blood glucose to blood ketones. It is defined in the experimental metabolic approach for brain tumors by Prof. Thomas Seyfried from Boston College Biology Department [30]. According to the scientific research and several case studies it showed clear correlation with diminished inflammation markers in the brain tumors and regression and remission of the tumor.
- Breathing
Optimization of cellular oxygenation with Buteyko breathing normalization technique (BBT). It slowly normalizes cell metabolism and stop inflammation through optimization of breathing patterns. It activates the body’s natural production of hormones and chemical substances. Same chemicals used by the pharmaceutical industry in the production of modern medicinal drugs.
Optimization of breathing has a direct effect on mitochondrial respiration. Tools used in Sakharoff Protocol to optimize automatic breathing patterns combine BBT with breathing devices mentioned previously in this chapter.
The progress is measured through clearly defined measurement targets metabolic markers. Control Pause (CP) is one of the novel metabolic markers, that reflects the normality of the regulation of gas balance in the lungs, as well as the blood and body pH and thus reflects the level of disease. The CP can be measured with a stopwatch as a timing of involuntary reflexive muscle contractions - as a reaction to an unforced breath-holding. The founder of Buteyko Breathing optimization Technique (BBT) Dr. Konstantin Buteyko stated that the measurement target of 60 seconds correlates with the cell environment that is uninhabitable for cancerous tumor cells - while making the normal cells thrive [11,31]. This is especially useful for inoperable intrinsic, diffuse and multiforme tumors such as DIPG and GBM. People diagnosed with brain tumors often have a CP of 5-10 seconds.
GROUP 2 - Optimization of Energy Distribution and The 3 Areas of Resilience
Energy distribution and utilization by the body can be optimized through training of allostatic resilience to minimize energy loss—the difference between acquired and utilized energy. The effectiveness and allostatic resilience can be viewed as the ratio of Q (energy output) to W (energy input), called performance coefficient (CoP) [32].
NPMA in general can optimize energy utilization and CoP through structured training and lifestyle change, thus minimizing energy loss and increasing systemic efficiency. Energy distribution can be subdivided into three main areas (Allostatic resilience triangle) of practical training and lifestyle change.
Resilience in general affects ability to return to high utility state following perturbations [33]. It is hypothesized that resilience in humans can be enhanced through training of its three parts—mental, physical, and immune. In Sakharoff Protocol this is called “allostatic resilience triangle”.
- Mental resilience
In the human environment, mental resilience is a part of allostatic resilience that reflects the ability of the body to withstand psychological stressors and adapt to life tasks, maintaining normal hormonal balance and neuroendocrine signaling [34]. To optimize mental resilience, Sakharoff Protocol uses training of relaxation patterns through progressive active relaxation in combination with training of 1-pointed attention.
In the cellular environment, this resilience corresponds to the ability by the cell environment (ECM - ExtraCellular Matrix) to maintain proper signaling function by the cell.
- Physical resilience
In the human environment, physical resilience is a part of allostatic resilience that reflects the ability of the body to withstand, adapt, and recover from physical load and stressors. To optimize physical resilience, Sakharoff Protocol uses multipurpose training inspired by Dharma-Marga and Tibetan yoga, forefoot walking, jogging, bodyweight exercise, rebounder bouncing, as well as kettlebell training.
In the cellular environment, it is hypothesized that this resilience corresponds to the ability by the cellular environment (ECM) to maintain proper structural and adhesive support function by the cell mediated through the interstitial matrix and connective tissue [35].
- Immune resilience
Building up the vital immune system through structured daily exercise, activating the cascading effect of venous and lymphatic valve/ pump functions, starting from the plantar venous lymph pump in the feet and all the way upwards to the heart.
Paying special attention to sleep optimization for eliminating toxins from your body by cleansing/detoxing, restoring, and protecting the body cells on a daily basis, including the three pathways of cellular autophagy [36].
In the human environment, immune resilience is a part of allostatic resilience that reflects the ability of the body to withstand, adapt, and recover from opportunistic organisms and pathogens as bacteria, viruses, fungi, or protozoa. Among techniques used in Sakharoff Protocol to optimize immune resilience are forefoot walking/ jogging, 3D multipurpose exercise to promote in-movement lymph drain, as well as different types of cold exposure.
In the cellular environment, this resilience corresponds to the ability by the ECM to maintain proper flow, viscosity, and composition of extracellular fluid (ECF) as well as blood and plasma.
Why this BOOTCAMP works
I see that it’s mostly the strongest and most knowledgeable people that are able to choose non-invasive metabolic therapies. Because it’s actually requires absence of fear. I see many people like that succeed in my own practice.
The healing doesn't happen overnight. We engineered this BOOTCAMP to help you take active steps every single day during a period of 6 months. And we have a plan that have already succeeded reversing illnesses inclusive brain tumors as Glioblastoma Multiforme and other cancers, as CLL and AML leukemias, breast and ovarian cancers among others.
The environment is tailored to help healing succeed
The BEAT GBM Intensive Bootcamp environment is tailored specially for the newly diagnosed and their close relatives. The close relatives must take part in the learning process - because the profound lifestyle change can not be managed by a patient alone without deep understanding of the process by his/her close relatives.
The measurement of progress is an integral part of the process
This is a training environment where each family member and the family as a whole work each day together intensively - to cope with a terrifying diagnose. The whole family helps the diagnosed person to enter a domain of structured exercise and therapeutic lifestyle - and also to measure progress in the personal online sheet. The healing effect of Sakharoff Protocol is fully trackable through daily measurements of blood, breathing, sleep quality and other parameters - with automated graph building.
Clearly defined measurement targets
The whole BEAT GBM Intensive Bootcamp framework is targeted on several metabolic markers that are known to stop brain tumors (instead of traditional gene-specific tumor markers):
- Control Pause
We aim to reach Control Pause (CP) measurement target of 60 seconds. According to the founder of Buteyko Breathing optimization Technique Dr. Konstantin Buteyko and also according to my own experience training cancer clients this target CP makes the cell environment challenging - and later in the process uninhabitable for cancerous tumor cells - while making the normal cells thrive. This is especially useful for inoperable intrinsic, diffuse and multiforme tumors as DIPG and GBM. People diagnosed with brain tumors often have a CP of 5-10 seconds. Below you can see a graph showing the healing process of GBM, where the initial CP=10 sec reaches the target of CP=60 sec during 3 months. This is achieved by extensive training with The Sakharoff Protocol:
- G/K ratio
G/K ratio is a ratio of blood glucose to blood ketones. It is defined in the experimental metabolic approach for brain tumors by Prof. Thomas Seyfried from Boston College Biology Department[30]. According to the scientific research and several case studies it showed clear correlation with diminished inflammation markers in the brain tumors and regression and remission of the tumor.
Target value depends on condition and stage of keto-adaptation. Following target values are defined for brain tumors:
< 1 is the target value for 2nd adaptation stage
1-3 is the target value for the 3rd adaptation stage
We aim to reach the target value of G/K ratio at 2nd stage of ketogenic adaptation and slowly changes towards the 3rd stage of adaptation. With full compliance and strict nutritional regimen the 2nd stage of ketogenic adaptation can already be reached during the first month of the nutritional lifestyle change.
Below you can see a graph showing the healing process of GBM, where the initial average ratio G/K=60 reaching the target ratio of G/K=1 during 1 month (left side of the graph):
- Other measurement targets
Sleep measurement: nightly CP change (CP∆), nightly pulse fall (P∆) and others
Metabolic/ inflammation markers: Triglycerides/HDL ratio, CRP, Homocysteine, Vit D and others
The process and support setup is tailored to help healing succeed
We will also provide you with daily support to help you build a strong process and overcome the hardships with full compliance and minimum procrastination. Helping you to avoid procrastination by weekly nudging and practical daily application of psycho-physiological mental training techniques inspired by martial arts legacy - instead of psychotherapy as we know it. All of this is made especially to ensure your compliance - and by that ensure healing to happen.
Helping the family and friends to show empathy and understanding for the situation and what you are doing about it by including them into the daily work sessions.
Prerequisites that ensure healing to happen
Daily structured training according to our BOTCAMP guidelines can ensure healing to happen. It has following prerequisites:
This approach won't overwhelm you
After reading this amount of information you might feel overwhelmed. It's understandable, especially because of the need to take over personal responsibility for a deadly health condition.
Asking you for compliance with 2-4 hours daily effort might also seem overwhelming, especially because of tiredness and lack of energy that you might experience right now.
On the other hand - our bootcamp framework consist of small steps - that are perfectly manageable. They are tailored to be implemented with small daily routines - at slowly incrementing pace.
The bootcamp will give you community with active peers dedicated to understand and implement the daily learning. You will greatly benefit from this form of active support.
Last but not least you will feel energized by the fact that you are taking personal responsibility and active steps on the quest to win the life back.
The completely unique part of this bootcamp is the ability to directly contact the main trainer and educator every day during the week. You can not find this personal level of support anywhere else.
Remember, it's only action that brings change – grab this unique opportunity.
Reality Check.
Is There An Alternative?
GBM survival rates are one of the shortest of all brain tumors:
Clinical trials of targeted therapies brought little survival benefits to GBM patients [1,37]. As you might already know, their median life prolonging effect is around 12 months in average, despite of lots of scientific trials [37,38].
GBM is considered incurable by conventional targeted approaches like chemotherapy, radiation and surgery because they don't change the environment in the brain in the long term - but only target the symptoms. It doesn't change the long-term prognosis for very agressive cancer cell populations with high grade of heterogeneity and diffusion among the normal cells.
Any questions? Book a free 15-min call with Misha Sakharoff
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Personal message for you
Can one human being be a telecom engineer, a project manager, a jazz musician, a breathing therapist - at the same time? For me the answer is yes – with the addition of love and excitement.
Thus I am hardly really surprised that I recently found myself working as a practical health trainer and at the same time writing my first scientific paper on integrative health for the medical publisher Elsevier while at the same time teaching doctors and other health professionals in my own certification program, The Sakharoff Protocol.
What has driven me all the way is a deep belief in balance - all things in nature, society and technology are interdependent. Imbalances can be solved when we detect the point of failure.
I have also been driven by a deep longing after purpose, and today I can say that not only did I find my purpose. It also found me. And we are working overtime together to bring a new health paradigm into the world.
In my work with Alzheimer's patients and Glioblastoma patients I have found a striking common cause. In both cases it seems that the human environment and behaviour can cause different problems in the brain environment for the 2 different groups of brain cells.
In one case, when the human environment is suboptimal, it can make the neurons degenerate and die. Then the neurodegenerative disease is triggered - one of which is Alzheimer's disease.
In another case, when the human environment is suboptimal it can make helper cells (glia) become cancerous and form cancerous tumors as Glioblastoma or DIPG.
In both cases the causes are the same - human environment and lifestyle. The only difference is in the personal genetic setup of the two people, that will trigger uninhibited cell division for one case - or cell degeneration and death in another case.
The difference lies in the different degree of metabolic flexibility of the two groups of brain cells. The neurons are very simple and inflexible cells. The helper cells (glia) have more sophisticated and flexible structure and function.
When your genetic setup includes some compromised gene pairs that mostly affect brain neurons - they are forced to change. Being simple and inflexible they can only degenerate and die. Then you are most probable to develop Alzheimer's.
When your genetic setup includes some compromised gene pairs that mostly affect glia cells - they are forced to change. Being more sophisticated and flexible in structure and function they can mutate to survive. Then you are most probable to develop a brain tumor.
These and other severe conditions caused by human environment and behaviour - also share another similarity. When targeted with medicine, surgery or radiation, the causes are left untouched to eventually produce new symptoms in the future.
The metabolic approach is a slow process, but it does the job changing the human environment and behaviour - thus improving the environment for the cells and the whole body. If and when you comply and stick to the strict regimen, compliance heals. If not – passivity can be and very often is mortal.
Working with such deadly diagnoses can be an ordeal. In my work I have had both wins and losses. A close friend first won, and then lost, his battle with GBM. And I witnessed a young girl diagnosed with DIPG having the last few months of her life darkened by a whole array of medical errors.
Luckily I have also seen many clients recover from diseases regarded by conventional medicine as incurable and reach a state of what they claimed was better health than ever before.
These life lessons learned from experience have helped me formulate the following:
Misha Sakharoff
References - Scientific Studies
- GBM Facts, Glioblastoma Multiforme - The Terminator:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC33993/ - Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637314/ - Ian F. Tannock, M.D., Ph.D., and John A. Hickman, D.Sc., Limits to Personalized Cancer Medicine:
https://www.nejm.org/doi/pdf/10.1056/NEJMsb1607705 - Altered energy metabolism in cancer – A unique opportunity for therapeutic intervention:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572003/ - Cancer as a metabolic disease: implications for novel therapeutics:
http://www.ncbi.nlm.nih.gov/pubmed/24343361 - T.N. Seyfried, Cancer as a metabolic disease: on the origin, management, and prevention of cancer, John Wiley & Sons, Inc, A. Hoboken, NJ, 2012. ISBN: 978-0470584927, ISBN:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102745/ - Metabolic alterations in cancer cells and therapeutic implications: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013402/
- T. Ferriss, Tools of Titans, Boston, Houghton Mifflin Harcourt Publishing Company, 2016. Interview with Dominic D'Agostino.
- Z. Clemens, C. Toth, TREATMENT OF HIGH-GRADE BRAIN TUMOR USING THE PALEOLITHIC KETOGENIC DIET (PKD): THREE CASES:
https://www.researchgate.net/publication/322570681_TREATMENT_OF_HIGH-GRADE_BRAIN_TUMOR_USING_THE_PALEOLITHIC_KETOGENIC_DIET_PKD_THREE_CASES - M.J. Bissell, H.G. Hall, G. Parry, Dynamic reciproity: How does the extracellular matrix direct gene expression?, J Theor Biol 99 (1982) 31–68:
https://www.sciencedirect.com/science/article/pii/0022519382903885?via%3Dihub - Normalbreathing.com. All clinical trials of the Buteyko method: http://www.normalbreathing.com/practice-trials.php
- M. Sakharoff, The Taste of Victory – Beating Cancer Natural Way:
https://sakharoff.com/the-taste-of-victory-beating-cancer-natural/ - M. Sakharoff, Learning points from the remission of Glioblastoma Multiforme brain tumor:
https://sakharoff.com/learning-points-remission-brain-cancer/ - State of affairs in use of steroids in DIPG: an international survey and a review of the literature:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901114/ - Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312317/ - Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525007/ - Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma:
https://www.researchgate.net/publication/320724464_Combination_of_EZH2_inhibitor_and_BET_inhibitor_for_treatment_of_diffuse_intrinsic_pontine_glioma - Gang Wu et al, Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas:
https://go.nature.com/2Nxcm0b - C.A. Godman, et al., Hyperbaric oxygen treatment induces antioxidant gene expression, Ann N Y Acad Sci 1197 (2010) 178–183:
https://doi.org/10.1111/j.1749-6632.2009.05393.x - T. Shimazu et al, Suppression of Oxidative Stress by Beta-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor:
http://www.insanemedicine.com/wp-content/uploads/2016/05/Suppression-of-oxidative-stress-by-%CE%B2-hydroxybutyrate-an-endogenous-histone-deacetylase-inhibitor..pdf - Mithu Storoni and Gordon T. Plant, The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis:
https://www.hindawi.com/journals/msi/2015/681289/#B66 - F. Karami, P. Mehdipour, Cancer Genetics and Psychotherapy:
https://bit.ly/2wpuUZU - M.A. Makary, M. Daniel, Medical error—the third leading cause of death in the US, BMJ 353 (2016) i2139:
https://doi.org/10.1136/bmj.i2139 - B.T. Seyfried, M. Kiebish, J. Marsh, P. Mukherjee, Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet, J Cancer Res Ther 5 (Suppl 1) (2009) S7–S15:
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=9;spage=7;epage=15;aulast=Seyfried - A. Poff et al, Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma:
https://www.ncbi.nlm.nih.gov/pubmed/29294371 - D.E. Bredesen, Reversal of cognitive decline: a novel therapeutic program, Aging (Albany, NY) 6 (2014) 707–717:
https://doi.org/10.18632/aging.100690 - Bissell, M.J. and Radisky, D. (2001) Putting Tumours in Context. Nature Review Cancer, 1, 46-54.
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- Fasting – Molecular Mechanisms and Clinical Applications:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/
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https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0009-2 - S.N. Paschenko, Study of application of the reduced breathing method in a combined treatment of breast cancer, Oncology (Kiev, Ukraine) 3 (1:) (2001) 77–78.
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Jersey, 2013244–245. - B.S. Oken, I. Chamine, W. Wakeland, A systems approach to stress, stressors and resilience in humans, Behav Brain Res 282 (2015) 144–154
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and health, John Wiley & Sons, Chichester, UK, 1988, pp. 629–649, 1988. - M. Abedin, N. King, Diverse evolutionary paths to cell adhesion, Trends Cell Biol 20 (12) (2010) 734–742. https://doi.org/10.1016/j.tcb.2010.08.002
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- M.H.A. Jansen et al, Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology:
http://www.stichtingsemmy.nl/wp-content/uploads/Jansen-Cancer-Treatment-Rev-20121.pdf - B. Benitez, Brainstem Tumours in Children:
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About Sakharoff Integrative Health
OUR VISION
- To empower people through integrative approach to rediscover the natural healing powers of their body, so they can take back responsibility for their health.
- To move from sick-care to health-care and towards non-invasive metabolic therapies – instead of constantly finding new genetic pathways to promote the current business model based on creation of new highly invasive chemical drugs.
- To bring forth a paradigm shift towards education instead of medication.
- To move back to the old model of medicine. Here, doctors were rewarded for their success in keeping their patients healthy - instead of being paid for trying to heal them when they got sick.
OUR STRATEGY
- Sakharoff Integrative Health protocol is a NPMA - Non-Pharmacological Metabolic Approach. As such it does no harm in the medical sense, it does not use any medical substances and basically doesn’t require any special equipment. We don’t sell neither the substances or the equipment. We only provide education and training to optimize the body functions essential for health and resilience. We also provide daily assistance to our clients to ensure 100% compliance regarding their activity and measurement regimens.
- Sakharoff Protocol promotes not either-or, but both-and. It means that the idea of integrative health has to be promoted. We connect the dots - not only nutrition, not only breathing, not only movement but all of that combined in one process.
- Sakharoff Protocol is in many ways complementary to the work of doctors that are openminded. Our common understanding is that the source of chronic diseases is metabolic dysfunction triggered by wrong lifestyle, through expression of a person's unique DNA.
- Sakharoff Protocol uses scientific research studies as the foundation for its core teachings and exercises.
- Sakharoff Protocol looks at triggers and causes of the disease - not only the symptoms. The protocol promotes understanding of lifestyle disease as syndrome with metabolic disfunction - multi-factorial condition with a bouquet of symptoms. Eg. people with Alzheimer’s most often than not get both diabetes and cardiovascular disease and other symptoms of metabolic dysfunction.
- Sakharoff Integrative Health work on two levels of interest. Firstly, helping individual person taking responsibility for his/her own health. Secondly, with the whole society, facilitating the paradigm shift from the practice of conventional allotropic medicine towards the idea of integrative metabolic health.
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